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In Utero Exposure to Phenobarbital and Intelligence Deficits in Adult Men JAMA 274:1518-1525, Reinisch,J.M.,et al, 1995 See this aricle in Pubmed Article Abstract Men exposed prenatally to phenobarbital had significantly lower verbal intelligence score(approximately 0.5 SD)than predicted.Lower socioeconomic status and being the offspring of an"unwanted"pregnancy increased the magnitude of the negative effects.Exposure that included the last trimester was the most detrimental.Phenobarbital exposure during early development can have long term deleterious effects on cognitive performance.Detrimental environmental conditions can interact with prenatal biological insult to magnify negative outcomes.Physicians are urged to use increased caution in prescribing such medications during pregnancy.

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(click to filter results - removes previous filter) adverse drug reaction anticonvulsants anticonvulsants,cognitive function with anticonvulsants,untoward effects of cognition intellectual deficit intelligence quotient intrauterine phenobarbital psychological testing

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